Six division matchups and Kirk Cousins' return to Minnesota highlight a lighter Week 14 schedule.

San Francisco 49ers running back Christian McCaffrey will not need surgery on his injured right knee but he will miss the rest of the regular season.

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills clinched their fifth straight AFC East title with a 35-10 victory over the San Francisco 49ers on a snowy Sunday night.

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” season-ending in the 49ers’ 35-10 loss to the Buffalo Bills on Sunday night.

Jake Moody redeemed himself after missing three earlier field goals by booting a 44-yarder as time expired to give the San Francisco 49ers a 23-20 victory over the Tampa Bay Buccaneers in running back Christian McCaffrey’s season debut.

Spending the first half of the season as a spectator while he worked his way back from Achilles tendinitis took its toll on San Francisco 49ers All-Pro running back Christian McCaffrey.

San Francisco 49ers All-Pro running back Christian McCaffrey has looked good in his first week back at practice after being sidelined by Achilles tendinitis and is on track to make his season debut Sunday against Tampa Bay.

San Francisco 49ers star receiver Brandon Aiyuk will miss the rest of the season after tearing ligaments in his right knee.

San Francisco 49ers All-Pro running back Christian McCaffrey has traveled to Germany to consult with a specialist about his Achilles tendinitis.

Injuries already are accruing across the NFL, knocking several star players out and forcing teams to turn to backups and reserves.

The San Francisco 49ers have placed All-Pro running back Christian McCaffrey on injured reserve because of his lingering calf and Achilles tendon injuries.

All-Pro running back Christian McCaffrey has been ruled out of this weekend’s game for the San Francisco 49ers because of his lingering calf and Achilles’ injuries.

San Francisco coach Kyle Shanahan said All-Pro running back Christian McCaffrey could have played in the 49ers’ opener if it had been a playoff game but the team held him out to make sure his Achilles tendinitis didn’t become a more serious issue.

Aaron Rodgers’ long-awaited return to the field was spoiled by San Francisco as the 49ers got 147 yards rushing and a touchdown from fill-in back Jordan Mason in a 32-19 victory over the New York Jets.

San Francisco All-Pro running back Christian McCaffrey is listed as questionable for the season opener against the New York Jets with a sore calf and Achilles.

Aaron Rodgers knows all eyes are on him.

Christian McCaffrey grew up playing the Madden NFL video game with his brother, dreaming of being a player in the league one day.

The San Francisco 49ers have rewarded All-Pro running back Christian McCaffrey with a contract extension after he won the AP Offensive Player of the Year award in his first full season with the team.

Marvin Harrison Jr., Joe Alt, Kris Jenkins and Jonah Ellis have turned the NFL draft into a family affair.

A person with knowledge of the deal says the Baltimore Ravens have agreed to a two-year contract with free agent running back Derrick Henry.

Jauan Jennings’ historic Super Bowl milestone will turn into only a footnote after his San Francisco 49ers lost the game.

Super Bowl 58 in Las Vegas on Sunday is shaping up to be quite a doozy.

They're the plays that shaped this year's postseason.

Lamar Jackson was a near-unanimous choice for his second AP NFL Most Valuable Player award.

It's ever-present on the lips of Taylor Swift and the uniforms of both Super Bowl teams.

Coach Kyle Shanahan took some convincing before deciding it was worth trading a boatload of draft picks before last season’s trade deadline for Christian McCaffrey.

The Detroit Lions are just one win away from the first Super Bowl appearance in franchise history.

The four teams remaining in the NFL playoffs all have an aspect of their offense in common.

The San Francisco 49ers are back in a familiar spot facing a Detroit Lions team new to this stage.

The four remaining teams in the NFL playoffs may have a lesson to offer.

Lamar Jackson, Christian McCaffrey and Dak Prescott are finalists for The Associated Press 2023 NFL Most Valuable Player and Offensive Player of the Year awards.

The most taxing part of getting to the precipice of the Super Bowl only to fall short might be the long journey just to return to that stage for another shot.

Christian McCaffrey scored his second touchdown on a 6-yard run with 1:07 to play, and the San Francisco 49ers mounted their first second-half comeback of the season to beat the Green Bay Packers 24-21 in a divisional-round playoff game.

Christian McCaffrey, Tyreek Hill and Fred Warner are unanimous choices for The Associated Press 2023 NFL All-Pro Team.

The Carolina Panthers have fired general manager Scott Fitterer, one day after the team finished with an NFL-worst 2-15 record.

Brock Purdy and Tua Tagovailoa were selected to their first Pro Bowl as the starting quarterbacks for their respective conferences.

The San Francisco 49ers and their deep group of playmakers accomplished a rare feat.

NFL leading rusher Christian McCaffrey will miss San Francisco’s regular-season finale with a mild calf strain but should be ready to return for the playoffs.

Brock Purdy threw two touchdown passes and the San Francisco 49ers clinched the top seed in the NFC by beating the Washington Commanders 27-10.

Several wide receivers had milestone performances this past week, but no one could do what Amari Cooper did for the Cleveland Browns.

If a December matchup between the top two teams in the NFL didn’t provide high enough stakes, the league MVP could be decided Monday night when the San Francisco 49ers host the Baltimore Ravens.

When it comes to getting big games from playmakers, the New England Patriots and Green Bay Packers have been lacking at a historic level.

Christian McCaffrey scored three touchdowns, Charvarius Ward had two interceptions, including a pick-6, and the San Francisco 49ers clinched the NFC West while pushing their winning streak to six games with a 45-29 win over the Arizona Cardinals.

Deebo Samuel scored on a catch and a run and the San Francisco 49ers won their 11th straight division game, beating the Seattle Seahawks 28-16.

Christian McCaffrey rushed for 114 yards and two touchdowns in the first half, and the San Francisco 49ers built a 21-point lead by halftime in rolling to a 31-13 win over the Seattle Seahawks.

Christian McCaffrey has been scoring at a record-setting pace so far this season.

Kirk Cousins connected with rookie Jordan Addison for two first-half touchdowns, Camryn Bynum intercepted San Francisco’s Brock Purdy twice in the fourth quarter, and the Minnesota Vikings beat the 49ers 22-17.

San Francisco 49ers receiver Deebo Samuel will miss at least the next two games with a hairline fracture in his shoulder.

Kyle Shanahan and Mike McDaniel spent years together scheming ways to exploit NFL defenses.

When the San Francisco 49ers dealt a bevy of draft picks to Carolina last October for Christian McCaffrey, some skeptics asked whether they overpaid for a running back in a passing league.

Christian McCaffrey scored a touchdown in his 12th straight game, Brock Purdy threw two TD passes and the San Francisco 49ers won their 13th straight regular season game, 30-12 over the New York Giants.

Fourteen NFL teams are 1-1 and Pro Picks also has an even record through two weeks.

The AFC came into the season with the lion’s share of the top quarterbacks and Super Bowl contenders led by passers like Patrick Mahomes, Josh Allen and Joe Burrow.

Brock Purdy threw for 220 yards and two touchdowns to Brandon Aiyuk and the San Francisco 49ers drilled the Pittsburgh Steelers 30-7.

The value of running backs in the NFL has dropped precipitously in recent years as teams rely more on the passing game to succeed.

Saquon Barkley and the New York Giants failed to reach an agreement on a long-term contract extension by Monday’s deadline for franchised players, leaving the star running back with the option of playing for the tag-mandated $10.1 million salary or maybe taking the season off.

The San Francisco 49ers got a jolt offensively when they made the bold decision in October to trade four draft picks to add Christian McCaffrey to an already deep group of playmakers.

Christian McCaffrey scored the go-ahead touchdown on a 2-yard run in the fourth quarter and San Francisco’s defense did the rest, sending the 49ers to their second straight NFC title game with a 19-12 victory over the Dallas Cowboys.

Brock Purdy threw three touchdown passes and ran for a fourth score in his playoff debut, leading the San Francisco 49ers to a 41-23 victory over the Seattle Seahawks in a wild-card game.

Wild-card weekend is all about familiarity.

Brock Purdy threw three touchdown passes for his sixth straight game with multiple TDs and the San Francisco 49ers clinched the No. 2 seed in the NFC playoffs with a 38-13 victory over the Arizona Cardinals.

Tashaun Gipson intercepted Jarrett Stidham in overtime and returned it 56 yards, setting up Robbie Gould’s 23-yard field goal that gave the San Francisco 49ers a 37-34 win over the Las Vegas Raiders.

Brock Purdy threw two touchdown passes and ran for another score in his first career start and San Francisco’s vaunted defense spoiled Tom Brady’s Bay Area homecoming with a 35-7 victory over the Tampa Bay Buccaneers.

Christian McCaffrey ran for the go-ahead touchdown with 7:54 to play, and the San Francisco 49ers beat the Los Angeles Chargers 22-16 in their first game back from a bye week.

The NFL trade deadline turned into a frenzy with 15 teams making 10 deals involving 12 players and several draft picks.

Christian McCaffrey became the 11th player in NFL history with a rushing touchdown, a passing touchdown and a receiving touchdown in one game, and the San Francisco 49ers extended their regular-season mastery over the Rams to four full years with a 31-14 victory over Los Angeles.

San Francisco 49ers playmaker Deebo Samuel will miss Sunday’s key NFC West showdown against the rival Los Angeles Rams with an injured hamstring.

The Los Angeles Rams are used to making the NFL’s boldest moves and getting the big-name players they want.

Patrick Mahomes threw for 424 yards and three touchdowns to rally Kansas City back from another double-digit deficit in the Chiefs’ 44-23 victory over the San Francisco 49ers.

Days after trading star running back Christian McCaffrey, the Carolina Panthers ran for a season-high 173 yards and rolled past Tom Brady and the Tampa Bay Buccaneers 21-3.

General manager John Lynch still views his San Francisco 49ers as a Super Bowl contender despite a string of injuries, lackluster performances and a 3-3 start to the season.

Some might say it’s a rebuild.

The San Francisco 49ers have acquired star running back Christian McCaffrey from the Carolina Panthers for a haul of draft picks.

According to a person familiar with the situation, the Carolina Panthers are considering trading 2019 All-Pro running back Christian McCaffrey if they get something significant in return.

Can we finally start Tony Pollard.

Nine home teams are underdogs in Week 3.

Patrick Mahomes loses sleep preparing for Thursday night games.

Sam Darnold threw a touchdown pass during the Carolina Panthers' 23-21 preseason-opening victory at the Washington Commanders to give him a highlight in the quarterback competition against Baker Mayfield.

Training camps opened across the NFL and the biggest offseason question remains unanswered.

Brendan Smith scored a short-handed goal late in the second period while Antti Raanta finished with 21 saves to help the Carolina Hurricanes beat the New York Rangers 2-0, taking a 2-0 lead in their second-round playoff series.

Every year, players in every NFL city fail to meet expectations.

Here are some athletes who were money in the bank for sports bettors this year: Indianapolis Colts running back Jonathan Taylor, Tampa Bay Buccaneers receiver Mike Evans and Los Angeles Angels star Shohei Ohtani.

Los Angeles Rams receiver Odell Beckham Jr. has been added to the COVID-19 reserve list as the NFL reports 28 more positive tests among players.

Carolina Panthers running back Christian McCaffrey will miss the remainder of the season with an ankle injury.

Jaylen Waddle had nine catches for a season-best 137 yards and a touchdown, and the Miami Dolphins forced Cam Newton into one of the worst statistical days of his career on the way to beating the Carolina Panthers 33-10 on Sunday.

Cam Newton provided a flashback to his Superman days in his second debut with the Panthers He threw for one touchdown, ran for another and sparked Carolina to a 34-10 win over the Arizona Cardinals.

Panthers quarterback Cam Newton made it clear in a 30-minute teleconference Friday that he doesn’t hold any grudges about the team releasing him prior to the 2020 season, calling it “irrelevant” to him now.

Dak Prescott and Joe Burrow are the top contenders for the NFL's Comeback Player of the Year honors after bouncing back from injuries that ended their 2020 seasons early.

The Carolina Panthers have placed running back Christian McCaffrey on injured reserve, meaning he will miss at least the next three games with a hamstring injury.

About a third of the starting quarterbacks have missed time because of injuries, and Richard Sherman’s return to the NFL was hastened by Tampa Bay’s need at cornerback.

The Los Angeles Rams are the unanimous top team in the latest AP Pro32 poll.

The injury bug has bitten running back Christian McCaffrey again.

Sam Darnold threw for 304 yards and ran for two touchdowns, and the Carolina Panthers eased past the Houston Texans 24-9 despite losing Christian McCaffrey to a hamstring injury early in the second quarter.

Carolina running back Christian McCaffrey left Thursday night’s game against the Houston Texans with a hamstring injury and will not return.

Sam Darnold threw for 305 yards and two touchdowns, and the Carolina defense turned in another strong performance in a 26-7 win over the New Orleans Saints.

Don't expect the New Orleans Saints to cede bragging rights in the NFC South too easily.

The Denver Broncos are going with Teddy Bridgewater over Drew Lock as their starting quarterback.

Jacob Eason was efficient in place of the injured Carson Wentz, and rookie Sam Ehlinger delivered in the final quarter for the Indianapolis Colts.

Aaron Rodgers and Deshaun Watson appeared on the field at their teams’ first training camp practices.

From players getting COVID-19 vaccinations to relaxed coronavirus protocols to lineup issues, particularly at quarterback, the NFL faces a multitude of questions as training camps open.