Fitzpatrick threw for 350 yards and three touchdowns and the Dolphins sent the defending NFC champion San Francisco 49ers to their third straight home loss to open the season, 43-17 on Sunday. The 49ers (2-3) are the team with questions at quarterback after Jimmy Garoppolo got pulled at halftime after throwing two interceptions. Beathard replaced Garoppolo at the half and threw one TD pass but it wasn’t enough to keep the Niners from falling again at home. Fitzpatrick capitalized on that with a 32-yard TD pass to Williams. TARGET PRACTICEWith the Niners down starting cornerbacks Richard Sherman, Emmanuel Moseley and K’Waun Williams, the Dolphins took advantage of fill-in Brian Allen.