Plenty of playoff contenders suddenly find themselves dealing with major injuries to notable players as the college football season reaches its halfway point.

Kevin Jennings passed and rushed for career highs, Isaiah Nwokobia intercepted an end-zone pass with 2:23 left to seal it, and SMU overcame blowing a double-digit lead to beat No. 22 Louisville 34-27.

Bryce Young passed for three touchdowns and rushed for a fourth, Will Anderson Jr. scored on an interception return and No. 2 Alabama rolled to a 63-7 victory over Louisiana-Monroe.

With Jameson Williams and John Metchie III sidelined by injuries, Bryce Young had his Heisman Trophy-winning season effectively ended by a last-minute pick six in the College Football Playoff championship game.

Georgia coach Kirby Smart sees challenges everywhere for his defense — even with Alabama missing one of its top receivers.