San Francisco All-Pro running back Christian McCaffrey is listed as questionable for the season opener against the New York Jets with a sore calf and Achilles.

All-Pro left tackle Trent Williams ended his contract holdout and reported to the San Francisco 49ers to finalize a new deal that have him a significant raise and guaranteed money.

Patrick Mahomes and the Chiefs chasing history will be the hottest topic throughout the NFL season.

Contract disputes are playing a prominent role across the NFL this summer.

Trent Williams’ accomplishments are already worthy of a Hall of Fame career with 11 Pro Bowl bids, three first-team All-Pro selections and near universal recognition as the best left tackle of his generation.

The San Francisco 49ers made the kind of decision that could set a franchise back for years when they traded three first-round picks to draft Trey Lance third overall in 2021.

Christian McCaffrey, Tyreek Hill and Fred Warner are unanimous choices for The Associated Press 2023 NFL All-Pro Team.

Brock Purdy and Tua Tagovailoa were selected to their first Pro Bowl as the starting quarterbacks for their respective conferences.

Any question about Trent Williams' value to San Francisco’s offense was dispelled by what the 49ers have done in his absence.

San Francisco 49ers receiver Deebo Samuel will miss at least the next two games with a hairline fracture in his shoulder.

Trent Williams spent much of the first decade of his NFL career being held back by playing for a dysfunctional organization in Washington.

2022 NFL All-Pro Team Roster.

Melvin Gordon scored from a yard out and Kareem Jackson recovered a fumble in the closing minutes Sunday night to secure Denver's 11-10 win over Jimmy Garoppolo and the San Francisco 49ers.

San Francisco quarterback Trey Lance was the featured attraction in Minnesota during joint practices between the 49ers and the Vikings.

Dak Prescott and the Dallas Cowboys couldn't take advantage of a home playoff game.

Five players, including dynamic pass catchers Cooper Kupp and Davante Adams, are unanimous choices for The Associated Press 2021 NFL All-Pro Team.

The San Francisco 49ers clinched a playoff spot with a 27-24 overtime victory over the NFC West champion Los Angeles Rams.

Randy Bullock kicked a 44-yard field goal with 4 seconds remaining and the banged-up Tennessee Titans rallied from a 10-point halftime deficit to beat the San Francisco 49ers 20-17.

Kings of Leon’s rock and roll journey has taken them from an NFT to the NFL.

(AP Photo/Jennifer Stewart, File)As the NFL opened its business year Wednesday, veterans Trent Williams, A.J. Williams also will get the biggest signing bonus ever for an offensive lineman at $30.1 million, as well as $55.1 million guaranteed. — Kansas City agreed to a $5 million contract for next season with three-time Pro Bowl guard Kyle Long, who will come out of retirement. — New England brought back center Ted Karras on a one-year, $4 million contract. Karras previously spent four seasons in New England, winning two Super Bowl rings as a utility offensive lineman and backup center to David Andrews.

FILE - San Francisco 49ers offensive tackle Trent Williams (71) looks on prior to an NFL football game against the Arizona Cardinals, in Glendale, Ariz., in this Saturday, Dec. 26, 2020, file photo. The San Francisco 49ers locked up their biggest potential free agent for the long term by agreeing to give star left tackle Trent Williams the richest contract ever for an offensive lineman. (AP Photo/Jennifer Stewart, File)SANTA CLARA, Calif. – The San Francisco 49ers locked up their biggest potential free agent for the long term by agreeing to give star left tackle Trent Williams the richest contract ever for an offensive lineman. “Trent’s a game changer,” said fullback Kyle Juszczyk, who signed a five-year contract to stay in San Francisco earlier in the week. Williams was graded as the top left tackle by Pro Football Focus and is now being paid that way as well.

Regardless, on Monday, two days before the NFL's 2021 business year begins, the 32 teams and agents for the players will be making deals. “Legal tampering, and tampering is illegal? AdOf course, free agency always is a buyer-beware situation. AdVoila: Lavonte David, a key linebacker, was re-signed, and several other key guys in the title run could be back. “We do have some money from a cap standpoint that we can spend; but again, it’s an interesting year.

Green Bay Packers wide receiver Marquez Valdes-Scantling, bottom left, and quarterback Aaron Rodgers (12) celebrate after connecting on a touchdown pass during the second half of an NFL football game against the San Francisco 49ers in Santa Clara, Calif., Thursday, Nov. 5, 2020. (AP Photo/Tony Avelar)SANTA CLARA, Calif. – Aaron Rodgers took advantage of the undermanned San Francisco 49ers rather than sympathizing with the team that dominated his Green Bay Packers twice last season. Rodgers threw for 305 yards and four touchdowns and the Packers overwhelmed the depleted 49ers 34-17 on Thursday night. DEPLETED ROSTERThe run of injuries and coronavirus rules left the 49ers with a shell of a roster, especially on offense. 49ers: CB K’Waun Williams (ankle) and S Jaquiski Tartt (toe) left the game and didn’t return.