Christian McCaffrey ran for the go-ahead touchdown with 7:54 to play, and the San Francisco 49ers beat the Los Angeles Chargers 22-16 in their first game back from a bye week.

Justin Herbert passed for three touchdowns and Tevaughn Campbell returned a Joe Mixon fumble 61 yards for a score, helping the Los Angeles Chargers hold off the Cincinnati Bengals for a 41-22 victory.

(AP Photo/AJ Mast)INDIANAPOLIS – Philip Rivers never flinched with the Indianapolis Colts facing a 21-0 first-half deficit Sunday. He went back to work and joined MVP quarterbacks Bert Jones and Peyton Manning in the Indianapolis Colts' record book. ... Mixon left in the first half with a right foot injury but returned at the start of the second half. ... DT Christian Covington and CB William Jackson III both got hurt in the second half and returned later. ... CB Xavier Rhodes and WR Marcus Johnson also were shaken up in the second half but returned.

___GREEN BAY AT TAMPA BAYPackers: RB Tyler Ervin, CB Kevin King, QB Jordan Love. ___NEW YORK JETS AT MIAMIJets: QB James Morgan, QB Sam Darnold, CB Quincy Wilson, LB Jordan Willis, T Mekhi Becton, DL Nathan Shepherd. Dolphins: B/WR Malcolm Perry, RB Salvon Ahmed, RB Jordan Howard, LB Kyle Van Noy, DE Jason Strowbridge. ___HOUSTON AT TENNESSEETexans: WR Keke Coutee, CB Cornell Armstrong, RB Buddy Howell, ILB Peter Kalambayi, OT Charlie Heck, TE Jordan Akins. ___ATLANTA AT MINNESOTAFalcons: CB Jordan Miller, RB Qadree Ollison, S Jaylinn Hawkins, RT John Wetzel, DE Takk McKinley.